When GLP-1 levels are adequate, the brain receives clear signals that you have eaten enough. When GLP-1 levels are low or when the brain becomes resistant to its signals, hunger persists even after a full meal.
Within seconds of being released into your bloodstream, an enzyme called dipeptidyl peptidase-4 (DPP-4) begins breaking GLP-1 apart. The half-life of natural GLP-1 is approximately 1.5 to 2 minutes.
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